Relationship between the conformation of bovine serum albumin and its digestion by pepsin.
نویسندگان
چکیده
منابع مشابه
The products of proteolysis of some purified proteins.
Recent studies on the digestion of proteins by the proteolytic enzymes of the gastrointestinal tract have resulted in a considerable revision of our concepts on how these enzymes act. Tiselius and Eriksson-Quensel (1) studied the mechanism of the peptic digestion of crystalline egg albumin by electrophoretic examination of the products of proteolysis. They observed that, as digestion proceeded,...
متن کاملLarge fragments of human serum albumin.
Large fragments of human serum albumin were produced by treatment of the native protein with pepsin at pH3.5. Published sequences of human albumin [Behrens, Spiekerman & Brown (1975) Fed. Proc. Fed. Am. Soc. Exp. Biol. 34, 591; Meloun, Moravek & Kostka (1975) FEBSLett.58, 134-137]were used to locate the fragments in the primary structure. The fragments support both the sequence and proposed dis...
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Investigation on interaction of azo dyes with bovine serum albumin as carrier protein will be important in the field of toxicology because of distribution and transportation of dyes in blood. In this regard, the interaction between the azo dye, trisodium (4E)-3-oxo-4-[(4- sulfonato-1- naphthyl) hydrazono] naphthalene-2,7-disulfonate (C20H11N2Na3O10S3), known as Amaranth and bovine serum albumin...
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Albumin from human, bovine, or rabbit serum supported the growth of concanavalin A-stimulated human thymus-derived lymphocytes equally well. This activity was completely abolished by pepsin digestion. It was shown for bovine serum albumin that the albumin molecule itself, and neither an impurity nor a factor bound to albumin was essential for the growth of lymphocytes. This conclusion was based...
متن کاملElectrophoretic demonstration of specific enzyme-substrate complex between pepsin and serum albumin. II. Inhibition of complex formation by acetyl-L-tryptophan and fatty acids.
The first paper of this series (1) described an electrophoretic demonstration of a complex between pepsin and bovine serum albumin during the course of the enzymatic hydrolysis of the latter. Several independent lines of evidence were presented that this complex is the Michaelis-Menten complex capable of being activated to give rise to reaction products. This communication reports the results o...
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ورودعنوان ژورنال:
- Biochimica et biophysica acta
دوره 236 1 شماره
صفحات -
تاریخ انتشار 1971